Crystal structures of alphavirus nonstructural protein 4 (nsP4) reveal an intrinsically dynamic RNA-dependent RNA polymerase fold

• Main Authors: Tan, Yaw Bia, Lello, Laura Sandra, Liu, Xin, Law, Yee-Song, Kang, Congbao, Lescar, Julien, Zheng, Jie, Merits, Andres, Luo, Dahai
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Medicine; Science::Biological sciences; Viral Protein; Virus RNA
• Online Access: https://hdl.handle.net/10356/161300
• Institution: Nanyang Technological University

Alphaviruses such as Ross River virus (RRV), chikungunya virus (CHIKV), Sindbis virus (SINV), and Venezuelan equine encephalitis virus (VEEV) are mosquito-borne pathogens that can cause arthritis or encephalitis diseases. Nonstructural protein 4 (nsP4) of alphaviruses possesses RNA-dependent RNA pol...