NS3 helicase from dengue virus specifically recognizes viral RNA sequence to ensure optimal replication

NS3 helicase from dengue virus specifically recognizes viral RNA sequence to ensure optimal replication

The protein–RNA interactions within the flavivirus replication complex (RC) are not fully understood. Our structure of dengue virus NS3 adenosine triphosphatase (ATPase)/helicase bound to the conserved 5′ genomic RNA 5′-AGUUGUUAGUCU-3′ reveals that D290 and R538 make specific interactions with G2 an...

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Bibliographic Details
Main Authors: Swarbrick, Crystall M. D., Basavannacharya, Chandrakala, Chan, Kitti W. K., Chan, Shu-Ann, Singh, Daljit, Wei, Na, Phoo, Wint Wint, Luo, Dahai, Lescar, Julien, Vasudevan, Subhash G.
Other Authors: School of Biological Sciences
Format: Article
Language:English
Published: 2018
Subjects:
Dengue Virus
RNA Replication
DRNTU::Science::Biological sciences::Genetics
Online Access:https://hdl.handle.net/10356/88387
http://hdl.handle.net/10220/45733
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Institution: Nanyang Technological University
Language: English

Internet

https://hdl.handle.net/10356/88387
http://hdl.handle.net/10220/45733

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