Profiling the 'deamidome' of complex biosamples using mixed-mode chromatography-coupled tandem mass spectrometry

• Main Authors: Sze, Siu Kwan, JebaMercy, Gnanasekaran, Ngan, SoFong Cam
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Biological sciences; Deamidation; Asparagine
• Online Access: https://hdl.handle.net/10356/161729
• Institution: Nanyang Technological University

Deamidation is a spontaneous degenerative protein modification (DPM) that disrupts the structure and function of both endogenous proteins and various therapeutic agents. While deamidation has long been recognized as a critical event in human aging and multiple degenerative diseases, research progres...