Disruption of dual homeostasis by a metal-organic framework nanoreactor for ferroptosis-based immunotherapy of tumor

• Main Authors: Zhang, Kai, Ma, Zhaoyu, Li, Shuting, Wu, Yang, Zhang, Jin, Zhang, Weiyun, Zhao, Yanli, Han, Heyou
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Chemistry::Biochemistry; Dual Homeostasis; Ferroptosis
• Online Access: https://hdl.handle.net/10356/161844
• Institution: Nanyang Technological University

Ferroptosis, a newfound non-apoptotic cell death pathway that is iron- and reactive oxygen species (ROS)-dependent, has shown a promise for tumor treatment. However, engineering ferroptosis inducers with sufficient hydrogen peroxide (H2O2) and iron supplying capacity remains a great challenge. To ad...