Prostaglandin A2 interacts with Nurr1 and ameliorates behavioral deficits in Parkinson's disease fly model

Prostaglandin A2 interacts with Nurr1 and ameliorates behavioral deficits in Parkinson's disease fly model

The orphan nuclear receptor Nurr1 is critical for the development, maintenance, and protection of midbrain dopaminergic neurons. Recently, we demonstrated that prostaglandins E1 (PGE1) and PGA1 directly bind to the ligand-binding domain (LBD) of Nurr1 and stimulate its transcriptional activation fun...

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Bibliographic Details
Main Authors: Rajan, Sreekanth, Toh, Hui Ting, Ye, Hong, Wang, Ziyin, Basil, Adeline Henry, Parnaik, Tanvi, Yoo, Jun Yeob, Lim, Kah-Leong, Yoon, Ho Sup
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Article
Language:English
Published: 2022
Subjects:
Science::Medicine
Nuclear Receptor
Nurr1
Online Access:https://hdl.handle.net/10356/162249
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Institution: Nanyang Technological University
Language: English

Internet

https://hdl.handle.net/10356/162249

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