Nuclear receptor Nurr1 agonists enhance its dual functions and improve behavioral deficits in an animal model of Parkinson’s disease

• Main Authors: Kim, Chun-Hyung, Han, Baek-Soo, Moon, Jisook, Kim, Deog-Joong, Shin, Joon, Rajan, Sreekanth, Nguyen, Quoc Toan, Sohn, Mijin, Kim, Won-Gon, Han, Minjoon, Jeong, Inhye, Kim, Kyoung-Shim, Lee, Eun-Hye, Tu, Yupeng, Naffin-Olivos, Jacqueline L., Park, Chang-Hwan, Ringe, Dagmar, Yoon, Ho Sup, Petsko, Gregory A., Kim, Kwang-Soo
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2015
• Subjects: NR4A2; Nurr1; Parkinson’s disease; Agonist; Drug target
• Online Access: https://hdl.handle.net/10356/81181; http://hdl.handle.net/10220/39159
• Institution: Nanyang Technological University

Parkinson’s disease (PD), primarily caused by selective degeneration of midbrain dopamine (mDA) neurons, is the most prevalent movement disorder, affecting 1–2% of the global population over the age of 65. Currently available pharmacological treatments are largely symptomatic and lose their efficacy...