PGE1 and PGA1 bind to Nurr1 and activate its transcriptional function

• Main Authors: Rajan, Sreekanth, Jang, Yongwoo, Kim, Chun-Hyung, Kim, Woori, Toh, Hui Ting, Jeon, Jeha, Song, Bin, Serra, Aida, Lescar, Julien, Yoo, Jun Yeob, Beldar, Serap, Ye, Hong, Kang, Congbao, Liu, Xue-Wei, Feitosa, Melissa, Kim, Yeahan, Hwang, Dabin, Goh, Geraldine, Lim, Kah-Leong, Park, Hye Min, Lee, Choong Hwan, Oh, Sungwhan F., Petsko, Gregory A., Yoon, Ho Sup, Kim, Kwang-Soo
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Chemistry; Source Data; Extended Data
• Online Access: https://hdl.handle.net/10356/155280
• Institution: Nanyang Technological University

The orphan nuclear receptor Nurr1 is critical for the development, maintenance and protection of midbrain dopaminergic (mDA) neurons. Here we show that prostaglandin E1 (PGE1) and its dehydrated metabolite, PGA1, directly interact with the ligand-binding domain (LBD) of Nurr1 and stimulate its trans...