Direct identification of A-to-I editing sites with nanopore native RNA sequencing

• Main Authors: Nguyen, Tram Anh, Heng, Joel Jia Wei, Kaewsapsak, Pornchai, Kok, Louis Eng Piew, Stanojević, Dominik, Liu, Hao, Cardilla, Angelysia, Praditya, Albert, Yi, Zirong, Lin, Mingwan, Aw, Ashley Jong Ghut, Ho, Yin Ying, Peh, Esther Kai Lay, Wang, Yuanming, Zhong, Qixing, Heraud-Farlow, Jacki, Xue, Shifeng, Reversade, Bruno, Walkley, Carl, Ho, Ying Swan, Šikić, Mile, Wan, Yue, Tan, Meng How
• 其他作者: School of Chemical and Biomedical Engineering
• 格式: Article
• 語言: English
• 出版: 2022
• 主題: Engineering::Bioengineering; Science::Biological sciences; Gene Expression; RNA Editing
• 在線閱讀: https://hdl.handle.net/10356/162250

Inosine is a prevalent RNA modification in animals and is formed when an adenosine is deaminated by the ADAR family of enzymes. Traditionally, inosines are identified indirectly as variants from Illumina RNA-sequencing data because they are interpreted as guanosines by cellular machineries. However,...