Formation of RNA G-wires by G₄C₂ repeats associated with ALS and FTD

• المؤلفون الرئيسيون: Bose, Krishnashish, Maity, Arijit, Ngo, Khac Huy, Vandana, J. Jeya, Shneider, Neil A., Phan, Anh Tuân
• مؤلفون آخرون: School of Physical and Mathematical Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2022
• الموضوعات: Science::Biological sciences; G-Quadruplex; C9ORF72
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/162435

In the neurodegenerative disorders amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), expansion of the G4C2 hexanucleotide repeat in the gene C9orf72 is a most common known cause of the disease. Here we use atomic force microscopy (AFM) and gel electrophoresis to visualize the fo...