Lack of ZnT8 protects pancreatic islets from hypoxia- and cytokine-induced cell death

• Main Authors: Karsai, Maria, Zuellig, Richard A., Lehmann, Roger, Cuozzo, Federica, Nasteska, Daniela, Luca, Edlira, Hantel, Constanze, Hodson, David J., Spinas, Giatgen A., Rutter, Guy A., Gerber, Philipp A.
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Medicine; Beta Cell; Hypoxia
• Online Access: https://hdl.handle.net/10356/162958
• Institution: Nanyang Technological University

Pancreatic β-cells depend on the well-balanced regulation of cytosolic zinc concentrations, providing sufficient zinc ions for the processing and storage of insulin, but avoiding toxic effects. The zinc transporter ZnT8, encoded by SLC30A8,is a key player regarding islet cell zinc homeostasis, and p...