Lack of ZnT8 protects pancreatic islets from hypoxia- and cytokine-induced cell death
Pancreatic β-cells depend on the well-balanced regulation of cytosolic zinc concentrations, providing sufficient zinc ions for the processing and storage of insulin, but avoiding toxic effects. The zinc transporter ZnT8, encoded by SLC30A8,is a key player regarding islet cell zinc homeostasis, and p...
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Main Authors: | Karsai, Maria, Zuellig, Richard A., Lehmann, Roger, Cuozzo, Federica, Nasteska, Daniela, Luca, Edlira, Hantel, Constanze, Hodson, David J., Spinas, Giatgen A., Rutter, Guy A., Gerber, Philipp A. |
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Other Authors: | Lee Kong Chian School of Medicine (LKCMedicine) |
Format: | Article |
Language: | English |
Published: |
2022
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Subjects: | |
Online Access: | https://hdl.handle.net/10356/162958 |
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Institution: | Nanyang Technological University |
Language: | English |
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