Decreased memory B cell frequencies in COVID-19 delta variant vaccine breakthrough infection

• Main Authors: Tay, Matthew Zirui, Rouers, Angeline, Fong, Siew-Wai, Goh, Yun Shan, Chan, Yi-Hao, Chang, Zi Wei, Xu, Weili, Tan, Chee Wah, Chia, Wan Ni, Torres-Ruesta, Anthony, Siti Naqiah Amrun, Huang, Yuling, Hor, Pei Xiang, Loh, Chiew Yee, Yeo, Nicholas Kim-Wah, Wang, Bei, Ngoh, Eve Zi Xian, Siti Nazihah Mohd Salleh, Chavatte, Jean-Marc, Lim, Alicia Jieling, Maurer-Stroh, Sebastian, Wang, Lin-Fa, Lin, Raymond Valentine Tzer Pin, Wang, Cheng-I, Tan, Seow-Yen, Young, Barnaby Edward, Leo, Yee Sin, Lye, David C., Renia, Laurent, Ng, Lisa F. P.
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Medicine; Correlate of Risk; COVID-19
• Online Access: https://hdl.handle.net/10356/163077
• Institution: Nanyang Technological University

The SARS-CoV-2 Delta (B.1.617.2) variant is capable of infecting vaccinated persons. An open question remains as to whether deficiencies in specific vaccine-elicited immune responses result in susceptibility to vaccine breakthrough infection. We investigated 55 vaccine breakthrough infection cases (...