Nγ-hydroxyasparagine: a multifunctional unnatural amino acid that is a good P1 substrate of asparaginyl peptide ligases

Nγ-hydroxyasparagine: a multifunctional unnatural amino acid that is a good P1 substrate of asparaginyl peptide ligases

Peptidyl asparaginyl ligases (PALs) are powerful tools for peptide macrocyclization. Herein, we report that a derivative of Asn, namely Nγ -hydroxyasparagine or Asn(OH), is an unnatural P1 substrate of PALs. By Asn(OH)-mediated cyclization, we prepared cyclic peptides as new matrix metalloproteinase...

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Bibliographic Details
Main Authors: Xia, Yiyin, To, Janet, Chan, Ning-Yu, Hu, Side, Liew, Heng Tai, Balamkundu, Seetharamsing, Zhang, Xiaohong, Lescar, Julien, Bhattacharjya, Surajit, Tam, James P., Liu, Chuan-Fa
Other Authors: School of Biological Sciences
Format: Article
Language:English
Published: 2022
Subjects:
Science::Biological sciences
Amino Acids
Enzymes
Online Access:https://hdl.handle.net/10356/163147
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Institution: Nanyang Technological University
Language: English

Internet

https://hdl.handle.net/10356/163147

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