Study of Ube3a knockdown and expression in the in vitro system.

• Main Author: Ng, Xiang Wen.
• Other Authors: Chen Ken-Shiung
• Format: Final Year Project
• Language: English
• Published: 2009
• Subjects: DRNTU::Science::Biological sciences::Molecular biology
• Online Access: http://hdl.handle.net/10356/16321
• Institution: Nanyang Technological University

Angelman syndrome (AS) is a neurological disorder which is caused by loss of maternally expressed genes on the human chromosome 15q11-q13 in the brain. AS patients show signs of mental retardation, seizures, lack of speech and ataxic gait. In this study, we would like to look into Ube3a, whose mutat...