Rubicon-deficiency sensitizes mice to mixed lineage kinase domain-like (MLKL)-mediated kidney ischemia-reperfusion injury

• Main Authors: Tonnus, Wulf, Locke, Sophie, Meyer, Claudia, Maremonti, Francesca, Eggert, Lena, von Mässenhausen, Anne, Bornstein, Stefan R., Green, Douglas R., Linkermann, Andreas
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Medicine; Double Stranded DNA; Acute Kidney Failure
• Online Access: https://hdl.handle.net/10356/163248
• Institution: Nanyang Technological University

The cytosolic protein rubicon (RUBCN) has been implicated in the removal of necrotic debris and autoimmunity. However, the role of RUBCN in models of acute kidney injury (AKI), a condition that typically involves necrotic kidney tubules, was not investigated. Here, we demonstrate that RUBCN-deficien...