Population genomics confirms acquisition of drug-resistant Aspergillus fumigatus infection by humans from the environment

• Main Authors: Rhodes, Johanna, Abdolrasouli, Alireza, Dunne, Katie, Sewell, Thomas R., Zhang, Yuyi, Ballard, Eloise, Brackin, Amelie P., van Rhijn, Norman, Chown, Harry, Tsitsopoulou, Alexandra, Posso, Raquel B., Chotirmall, Sanjay Haresh, McElvaney, Noel G., Murphy, Philip G., Talento, Alida Fe, Renwick, Julie, Dyer, Paul S., Szekely, Adrien, Bowyer, Paul, Bromley, Michael J., Johnson, Elizabeth M., Lewis White, P., Warris, Adilia, Barton, Richard C., Schelenz, Silke, Rogers, Thomas R., Armstrong-James, Darius, Fisher, Matthew C.
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Medicine; Antifungal Resistance; Aspergillosis
• Online Access: https://hdl.handle.net/10356/163382
• Institution: Nanyang Technological University

Infections caused by the fungal pathogen Aspergillus fumigatus are increasingly resistant to first-line azole antifungal drugs. However, despite its clinical importance, little is known about how susceptible patients acquire infection from drug-resistant genotypes in the environment. Here, we presen...