BF₃-promoted reactions of α-amino acetals with alkynes to 2,5-disubstituted pyrroles
An efficient BF₃-promoted cyclization of α-amino acetals with alkynes for the assembly of substituted pyrroles has been developed. This cascade process uses easily accessible α-amino acetals as raw materials and can be achieved under mild conditions through a simple metal-free operation.
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sg-ntu-dr.10356-1634942022-12-07T07:39:24Z BF₃-promoted reactions of α-amino acetals with alkynes to 2,5-disubstituted pyrroles Gao, Zhi-Yuan He, Yu Li, Lan-Yang Tian, Jie-Sheng Loh, Teck-Peng School of Physical and Mathematical Sciences Science::Chemistry Cascade Process Cyclizations An efficient BF₃-promoted cyclization of α-amino acetals with alkynes for the assembly of substituted pyrroles has been developed. This cascade process uses easily accessible α-amino acetals as raw materials and can be achieved under mild conditions through a simple metal-free operation. Ministry of Education (MOE) The authors gratefully acknowledge the generous financial support from Nanjing Tech University, the Fundamental Research Funds for the Central Universities (D5000210701), and Tier 1 Grant M4012045.110 (RG12/18-S) from the Ministry of Education of Singapore. 2022-12-07T07:39:24Z 2022-12-07T07:39:24Z 2022 Journal Article Gao, Z., He, Y., Li, L., Tian, J. & Loh, T. (2022). BF₃-promoted reactions of α-amino acetals with alkynes to 2,5-disubstituted pyrroles. Organic Chemistry Frontiers, 9(12), 3317-3321. https://dx.doi.org/10.1039/d2qo00405d 2052-4129 https://hdl.handle.net/10356/163494 10.1039/d2qo00405d 2-s2.0-85133618180 12 9 3317 3321 en M4012045.110 (RG12/18-S) Organic Chemistry Frontiers © 2022 the Partner Organisations (The Chinese Chemical Society, Shanghai Institute of Organic Chemistry, and Royal Society of Chemistry). All rights reserved. |
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Science::Chemistry Cascade Process Cyclizations |
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Science::Chemistry Cascade Process Cyclizations Gao, Zhi-Yuan He, Yu Li, Lan-Yang Tian, Jie-Sheng Loh, Teck-Peng BF₃-promoted reactions of α-amino acetals with alkynes to 2,5-disubstituted pyrroles |
| description |
An efficient BF₃-promoted cyclization of α-amino acetals with alkynes for the assembly of substituted pyrroles has been developed. This cascade process uses easily accessible α-amino acetals as raw materials and can be achieved under mild conditions through a simple metal-free operation. |
| author2 |
School of Physical and Mathematical Sciences |
| author_facet |
School of Physical and Mathematical Sciences Gao, Zhi-Yuan He, Yu Li, Lan-Yang Tian, Jie-Sheng Loh, Teck-Peng |
| format |
Article |
| author |
Gao, Zhi-Yuan He, Yu Li, Lan-Yang Tian, Jie-Sheng Loh, Teck-Peng |
| author_sort |
Gao, Zhi-Yuan |
| title |
BF₃-promoted reactions of α-amino acetals with alkynes to 2,5-disubstituted pyrroles |
| title_short |
BF₃-promoted reactions of α-amino acetals with alkynes to 2,5-disubstituted pyrroles |
| title_full |
BF₃-promoted reactions of α-amino acetals with alkynes to 2,5-disubstituted pyrroles |
| title_fullStr |
BF₃-promoted reactions of α-amino acetals with alkynes to 2,5-disubstituted pyrroles |
| title_full_unstemmed |
BF₃-promoted reactions of α-amino acetals with alkynes to 2,5-disubstituted pyrroles |
| title_sort |
bf₃-promoted reactions of α-amino acetals with alkynes to 2,5-disubstituted pyrroles |
| publishDate |
2022 |
| url |
https://hdl.handle.net/10356/163494 |
| _version_ |
1753801153248755712 |