Arl15 upregulates the TGFβ family signaling by promoting the assembly of the Smad-complex

• Main Authors: Shi, Meng, Tie, Hieng Chiong, Divyanshu, Mahajan, Sun, Xiuping, Zhou, Yan, Boh, Boon Kim, Vardy, Leah A., Lu, Lei
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Biological sciences; Transactivator Protein; Signal Transduction
• Online Access: https://hdl.handle.net/10356/163669
• Institution: Nanyang Technological University

The hallmark event of the canonical transforming growth factor β (TGFβ) family signaling is the assembly of the Smad-complex, consisting of the common Smad, Smad4, and phos-phorylated receptor-regulated Smads. How the Smad-complex is assembled and regulated is still unclear. Here, we report that act...