Checkpoint nano-PROTACs for activatable cancer photo-immunotherapy

• المؤلفون الرئيسيون: Zhang, Chi, Xu, Mengke, He, Shasha, Huang, Jingsheng, Xu, Cheng, Pu, Kanyi
• مؤلفون آخرون: Lee Kong Chian School of Medicine (LKCMedicine)
• التنسيق: مقال
• اللغة: English
• منشور في: 2023
• الموضوعات: Science::Chemistry; Cancer Immunotherapy; Checkpoint Blockade
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/164392

Checkpoint immunotherapy holds great potential to treat malignancies via blocking the immunosuppressive signaling pathways, which however suffers from inefficiency and off-target adverse effects. Herein, checkpoint nano-proteolysis targeting chimeras (nano-PROTACs) in combination with photodynamic t...