Checkpoint nano-PROTACs for activatable cancer photo-immunotherapy

• Main Authors: Zhang, Chi, Xu, Mengke, He, Shasha, Huang, Jingsheng, Xu, Cheng, Pu, Kanyi
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Chemistry; Cancer Immunotherapy; Checkpoint Blockade
• Online Access: https://hdl.handle.net/10356/164392
• Institution: Nanyang Technological University

Checkpoint immunotherapy holds great potential to treat malignancies via blocking the immunosuppressive signaling pathways, which however suffers from inefficiency and off-target adverse effects. Herein, checkpoint nano-proteolysis targeting chimeras (nano-PROTACs) in combination with photodynamic t...