Network reconstruction for trans acting genetic loci using multi-omics data and prior information

• Main Authors: Hawe, Johann S., Saha, Ashis, Waldenberger, Melanie, Kunze, Sonja, Wahl, Simone, Müller-Nurasyid, Martina, Prokisch, Holger, Grallert, Harald, Herder, Christian, Peters, Annette, Strauch, Konstantin, Theis, Fabian J., Gieger, Christian, Chambers, John Campbell, Battle, Alexis, Heinig, Matthias
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Medicine; Data Integration; Machine Learning
• Online Access: https://hdl.handle.net/10356/164536
• Institution: Nanyang Technological University

Background: Molecular measurements of the genome, the transcriptome, and the epigenome, often termed multi-omics data, provide an in-depth view on biological systems and their integration is crucial for gaining insights in complex regulatory processes. These data can be used to explain disease relat...