Human alpha cell transcriptomic signatures of types 1 and 2 diabetes highlight disease-specific dysfunction pathways

• Main Authors: Bosi, Emanuele, Marchetti, Piero, Rutter, Guy Allen, Eizirik, Decio Laks
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Medicine; Bioinformatics; Biological Sciences
• Online Access: https://hdl.handle.net/10356/164615
• Institution: Nanyang Technological University

Although glucagon secretion is perturbed in both T1D and T2D, the pathophysiological changes in individual pancreatic alpha cells are still obscure. Using recently curated single-cell RNASeq data from T1D or T2D donors and their controls, we identified alpha cell transcriptomic alterations consisten...