Human alpha cell transcriptomic signatures of types 1 and 2 diabetes highlight disease-specific dysfunction pathways

• Main Authors: Bosi, Emanuele, Marchetti, Piero, Rutter, Guy Allen, Eizirik, Decio Laks
• 其他作者: Lee Kong Chian School of Medicine (LKCMedicine)
• 格式: Article
• 語言: English
• 出版: 2023
• 主題: Science::Medicine; Bioinformatics; Biological Sciences
• 在線閱讀: https://hdl.handle.net/10356/164615
• 機構: Nanyang Technological University

Although glucagon secretion is perturbed in both T1D and T2D, the pathophysiological changes in individual pancreatic alpha cells are still obscure. Using recently curated single-cell RNASeq data from T1D or T2D donors and their controls, we identified alpha cell transcriptomic alterations consisten...