Chemical basis of combination therapy to combat antibiotic resistance

The antimicrobial resistance crisis is a global health issue requiring discovery and development of novel therapeutics. However, conventional screening of natural products or synthetic chemical libraries is uncertain. Combination therapy using approved antibiotics with inhibitors targeting innate r...

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Main Authors: Si, Zhangyong, Pethe, Kevin, Chan-Park, Mary B.
Other Authors: School of Chemical and Biomedical Engineering
Format: Article
Language:English
Published: 2023
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Online Access:https://hdl.handle.net/10356/164619
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-1646192023-02-11T23:33:45Z Chemical basis of combination therapy to combat antibiotic resistance Si, Zhangyong Pethe, Kevin Chan-Park, Mary B. School of Chemical and Biomedical Engineering Lee Kong Chian School of Medicine (LKCMedicine) Singapore Centre for Environmental Life Sciences and Engineering (SCELSE) Science::Chemistry::Biochemistry Antimicrobial Resistance Combination Therapy The antimicrobial resistance crisis is a global health issue requiring discovery and development of novel therapeutics. However, conventional screening of natural products or synthetic chemical libraries is uncertain. Combination therapy using approved antibiotics with inhibitors targeting innate resistance mechanisms provides an alternative strategy to develop potent therapeutics. This review discusses the chemical structures of effective β-lactamase inhibitors, outer membrane permeabilizers, and efflux pump inhibitors that act as adjuvant molecules of classical antibiotics. Rational design of the chemical structures of adjuvants will provide methods to impart or restore efficacy to classical antibiotics for inherently antibiotic-resistant bacteria. As many bacteria have multiple resistance pathways, adjuvant molecules simultaneously targeting multiple pathways are promising approaches to combat multi-drug-resistant bacterial infections. Ministry of Education (MOE) Submitted/Accepted version This work was funded and supported by the Singapore MOE Tier 3 grant (MOE2018-T3-1-003). 2023-02-07T05:23:54Z 2023-02-07T05:23:54Z 2023 Journal Article Si, Z., Pethe, K. & Chan-Park, M. B. (2023). Chemical basis of combination therapy to combat antibiotic resistance. JACS Au. https://dx.doi.org/10.1021/jacsau.2c00532 2691-3704 https://hdl.handle.net/10356/164619 10.1021/jacsau.2c00532 en MOE2018-T3-1-003 JACS Au © 2023 The Authors. All rights reserved. This paper was published by American Chemical Society in JACS Au and is made available with permission of The Authors. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Science::Chemistry::Biochemistry
Antimicrobial Resistance
Combination Therapy
spellingShingle Science::Chemistry::Biochemistry
Antimicrobial Resistance
Combination Therapy
Si, Zhangyong
Pethe, Kevin
Chan-Park, Mary B.
Chemical basis of combination therapy to combat antibiotic resistance
description The antimicrobial resistance crisis is a global health issue requiring discovery and development of novel therapeutics. However, conventional screening of natural products or synthetic chemical libraries is uncertain. Combination therapy using approved antibiotics with inhibitors targeting innate resistance mechanisms provides an alternative strategy to develop potent therapeutics. This review discusses the chemical structures of effective β-lactamase inhibitors, outer membrane permeabilizers, and efflux pump inhibitors that act as adjuvant molecules of classical antibiotics. Rational design of the chemical structures of adjuvants will provide methods to impart or restore efficacy to classical antibiotics for inherently antibiotic-resistant bacteria. As many bacteria have multiple resistance pathways, adjuvant molecules simultaneously targeting multiple pathways are promising approaches to combat multi-drug-resistant bacterial infections.
author2 School of Chemical and Biomedical Engineering
author_facet School of Chemical and Biomedical Engineering
Si, Zhangyong
Pethe, Kevin
Chan-Park, Mary B.
format Article
author Si, Zhangyong
Pethe, Kevin
Chan-Park, Mary B.
author_sort Si, Zhangyong
title Chemical basis of combination therapy to combat antibiotic resistance
title_short Chemical basis of combination therapy to combat antibiotic resistance
title_full Chemical basis of combination therapy to combat antibiotic resistance
title_fullStr Chemical basis of combination therapy to combat antibiotic resistance
title_full_unstemmed Chemical basis of combination therapy to combat antibiotic resistance
title_sort chemical basis of combination therapy to combat antibiotic resistance
publishDate 2023
url https://hdl.handle.net/10356/164619
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