Neuronal IRE-1 coordinates an organism-wide cold stress response by regulating fat metabolism

• المؤلفون الرئيسيون: Dudkevich, Reut, Koh, Jhee Hong, Beaudoin-Chabot, Caroline, Celik, Cenk, Lebenthal-Loinger, Ilana, Karako-Lampert, Sarit, Syed Ahmad-Albukhari, Thibault, Guillaume, Henis-Korenblit, Sivan
• مؤلفون آخرون: School of Biological Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2023
• الموضوعات: Science::Medicine; Caenorhabditis Elegans; ER Stress; RNA-Seq
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/164688
• المؤسسة: Nanyang Technological University

Cold affects many aspects of biology, medicine, agriculture, and industry. Here, we identify a conserved endoplasmic reticulum (ER) stress response, distinct from the canonical unfolded protein response, that maintains lipid homeostasis during extreme cold. We establish that the ER stress sensor IRE...