Novel method of fabricating hydroxyapatite incorporated 5-fluorouracil loaded poly (lactide-co-glycolide) microspheres

• Main Author: Lin, Julian Yuting.
• Other Authors: Lim Sierin
• Format: Final Year Project
• Language: English
• Published: 2009
• Subjects: DRNTU::Engineering::Chemical engineering::Biotechnology
• Online Access: http://hdl.handle.net/10356/16470
• Institution: Nanyang Technological University

Hydroxyapatite-incorporated PLGA-based microspheres loaded with 5-FU were prepared using the emulsification/solvent evaporation technique. The effects of hydroxyapatite-to-polymer ratio, dimethyl sulfoxide-to-dichloromethane ratio as well the effects of polymer inherent viscosity on encapsulation ef...