Biotechnological advances for improving natural pigment production: a state-of-the-art review

In current years, natural pigments are facing a fast-growing global market due to the increase of people’s awareness of health and the discovery of novel pharmacological effects of various natural pigments, e.g., carotenoids, flavonoids, and curcuminoids. However, the traditional production approach...

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Main Authors: Lyu, Xiaomei, Lyu, Yan, Yu, Hongwei, Chen, Wei Ning, Ye, Lidan, Yang, Ruijin
Other Authors: School of Chemical and Biomedical Engineering
Format: Article
Language:English
Published: 2023
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Online Access:https://hdl.handle.net/10356/164922
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-1649222023-12-29T06:49:43Z Biotechnological advances for improving natural pigment production: a state-of-the-art review Lyu, Xiaomei Lyu, Yan Yu, Hongwei Chen, Wei Ning Ye, Lidan Yang, Ruijin School of Chemical and Biomedical Engineering Engineering::Bioengineering Natural Pigments Microbial Cultivation In current years, natural pigments are facing a fast-growing global market due to the increase of people’s awareness of health and the discovery of novel pharmacological effects of various natural pigments, e.g., carotenoids, flavonoids, and curcuminoids. However, the traditional production approaches are source-dependent and generally subject to the low contents of target pigment compounds. In order to scale-up industrial production, many efforts have been devoted to increasing pigment production from natural producers, via development of both in vitro plant cell/tissue culture systems, as well as optimization of microbial cultivation approaches. Moreover, synthetic biology has opened the door for heterologous biosynthesis of pigments via design and re-construction of novel biological modules as well as biological systems in bio-platforms. In this review, the innovative methods and strategies for optimization and engineering of both native and heterologous producers of natural pigments are comprehensively summarized. Current progress in the production of several representative high-value natural pigments is also presented; and the remaining challenges and future perspectives are discussed. Published version This work was funded by the National Natural Science Foundation of China (22108097), Natural Science Foundation of Jiangsu Province (BK20200616), National Key Research and Development Program of China (Grant No. 2018YFA0901800), China Postdoctoral Science Foundation (2020M671339), and Zhejiang Provincial Natural Science Foundation of China (Grant No. LZ20B060002). 2023-02-27T07:59:51Z 2023-02-27T07:59:51Z 2022 Journal Article Lyu, X., Lyu, Y., Yu, H., Chen, W. N., Ye, L. & Yang, R. (2022). Biotechnological advances for improving natural pigment production: a state-of-the-art review. Bioresources and Bioprocessing, 9(1). https://dx.doi.org/10.1186/s40643-022-00497-4 2197-4365 https://hdl.handle.net/10356/164922 10.1186/s40643-022-00497-4 2-s2.0-85124016132 1 9 en Bioresources and Bioprocessing © The Author(s) 2022. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Engineering::Bioengineering
Natural Pigments
Microbial Cultivation
spellingShingle Engineering::Bioengineering
Natural Pigments
Microbial Cultivation
Lyu, Xiaomei
Lyu, Yan
Yu, Hongwei
Chen, Wei Ning
Ye, Lidan
Yang, Ruijin
Biotechnological advances for improving natural pigment production: a state-of-the-art review
description In current years, natural pigments are facing a fast-growing global market due to the increase of people’s awareness of health and the discovery of novel pharmacological effects of various natural pigments, e.g., carotenoids, flavonoids, and curcuminoids. However, the traditional production approaches are source-dependent and generally subject to the low contents of target pigment compounds. In order to scale-up industrial production, many efforts have been devoted to increasing pigment production from natural producers, via development of both in vitro plant cell/tissue culture systems, as well as optimization of microbial cultivation approaches. Moreover, synthetic biology has opened the door for heterologous biosynthesis of pigments via design and re-construction of novel biological modules as well as biological systems in bio-platforms. In this review, the innovative methods and strategies for optimization and engineering of both native and heterologous producers of natural pigments are comprehensively summarized. Current progress in the production of several representative high-value natural pigments is also presented; and the remaining challenges and future perspectives are discussed.
author2 School of Chemical and Biomedical Engineering
author_facet School of Chemical and Biomedical Engineering
Lyu, Xiaomei
Lyu, Yan
Yu, Hongwei
Chen, Wei Ning
Ye, Lidan
Yang, Ruijin
format Article
author Lyu, Xiaomei
Lyu, Yan
Yu, Hongwei
Chen, Wei Ning
Ye, Lidan
Yang, Ruijin
author_sort Lyu, Xiaomei
title Biotechnological advances for improving natural pigment production: a state-of-the-art review
title_short Biotechnological advances for improving natural pigment production: a state-of-the-art review
title_full Biotechnological advances for improving natural pigment production: a state-of-the-art review
title_fullStr Biotechnological advances for improving natural pigment production: a state-of-the-art review
title_full_unstemmed Biotechnological advances for improving natural pigment production: a state-of-the-art review
title_sort biotechnological advances for improving natural pigment production: a state-of-the-art review
publishDate 2023
url https://hdl.handle.net/10356/164922
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