Homocysteine metabolism pathway is involved in the control of glucose homeostasis: a cystathionine beta synthase deficiency study in mouse

• Main Authors: Cruciani-Guglielmacci, Céline, Meneyrol, Kelly, Denom, Jessica, Kassis, Nadim, Rachdi, Latif, Makaci, Fatna, Migrenne-Li, Stéphanie, Daubigney, Fabrice, Georgiadou, Eleni, Denis, Raphaël G., Sanchez-Archidona, Ana Rodriguez, Paul, Jean-Louis, Thorens, Bernard, Rutter, Guy A., Magnan, Christophe, Le Stunff, Hervé, Janel, Nathalie
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Medicine; Autonomic Nervous System; Insulin Secretion
• Online Access: https://hdl.handle.net/10356/165257
• Institution: Nanyang Technological University

Cystathionine beta synthase (CBS) catalyzes the first step of the transsulfuration pathway from homocysteine to cystathionine, and its deficiency leads to hyperhomocysteinemia (HHcy) in humans and rodents. To date, scarce information is available about the HHcy effect on insulin secretion, and the l...