Reconstituted TAD-size chromatin fibers feature heterogeneous nucleosome clusters

• المؤلفون الرئيسيون: Korolev, Nikolay, Zinchenko, Anatoly, Soman, Aghil, Chen, Qinming, Wong, Sook Yi, Berezhnoy, Nikolay V., Basak, Rajib, van der Maarel, Johan R. C., van Noort, John, Nordenskiöld, Lars
• مؤلفون آخرون: School of Biological Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2023
• الموضوعات: Science::Biological sciences; Histone; Chromatin
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/165451
• المؤسسة: Nanyang Technological University

Large topologically associated domains (TADs) contain irregularly spaced nucleosome clutches, and interactions between such clutches are thought to aid the compaction of these domains. Here, we reconstituted TAD-sized chromatin fibers containing hundreds of nucleosomes on native source human and lam...