Viral proteases activate the CARD8 inflammasome in the human cardiovascular system

• Main Authors: Nadkarni, Rhea, Chu, Wern Cui, Lee, Cheryl Q. E., Mohamud, Yasir, Yap, Lynn, Toh, Gee Ann, Beh, Sheryl, Lim, Radiance, Fan, Michelle Yiyun, Zhang, Lyanne Yizhuo, Robinson, Kim, Tryggvason, Karl, Luo, Honglin, Zhong, Franklin, Ho, Lena
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Medicine; Atherosclerotic Plaque; Cardiac Muscle Cell
• Online Access: https://hdl.handle.net/10356/165618
• Institution: Nanyang Technological University

Nucleotide-binding oligomerization domain (NBD), leucine-rich repeat (LRR) containing protein family (NLRs) are intracellular pattern recognition receptors that mediate innate immunity against infections. The endothelium is the first line of defense against blood-borne pathogens, but it is unclear w...