Chemical and enzymatic synthesis of Aureocin A53 peptide conjugates

• Main Author: Yip, Rayna Weiqin
• Other Authors: Liu Chuan Fa
• Format: Final Year Project
• Language: English
• Published: Nanyang Technological University 2023
• Subjects: Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/166612
• Institution: Nanyang Technological University

Aureocin A53 (AucA) is a bacteriocin holding great potential as a drug to combat antimicrobial resistance. Displaying activity against multidrug-resistant staphylococcal strains, AucA penetrates non-specifically to the cytoplasmic membrane, resulting in lysis. Here, the use of microwave-assisted sol...