Genetic modulators of Plasmodium falciparum parasites asexual fitness and resistance to clinical and preclinical compounds

• Main Author: Hong, Davin
• Other Authors: -
• Format: Final Year Project
• Language: English
• Published: Nanyang Technological University 2023
• Subjects: Science::Biological sciences::Microbiology::Drug Resistance; Science::Biological sciences::Genetics
• Online Access: https://hdl.handle.net/10356/167504
• Institution: Nanyang Technological University

Emergence of malarial Plasmodium falciparum KEL1/PLA1 co-lineage in Southeast Asia caused the failure of dihydroartemisin+piperaquine (DHA+PPQ). PfKelch (k13) C580Y mutation and plasmepsins 2/3 gene (pm2/3) amplification, markers of DHA and PPQ resistance respectively, are hallmarks of KEL1/PLA1 par...