Signalling inhibition by ponatinib disrupts productive alternative lengthening of telomeres (ALT)

• Main Authors: Kusuma, Frances Karla, Prabhu, Aishvaryaa, Tieo, Galen, Syed Moiz Ahmed, Dakle, Pushkar, Yong, Wai Khang, Pathak, Elina, Madan, Vikas, Jiang, Yan Yi, Tam, Wai Leong, Kappei, Dennis, Dröge, Peter, Koeffler, H. Phillip, Jeitany, Maya
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Biological sciences; Cell Signalling; DNA
• Online Access: https://hdl.handle.net/10356/168369
• Institution: Nanyang Technological University

Alternative lengthening of telomeres (ALT) supports telomere maintenance in 10-15% of cancers, thus representing a compelling target for therapy. By performing anti-cancer compound library screen on isogenic cell lines and using extrachromosomal telomeric C-circles, as a bona fide marker of ALT acti...