Activation function 1 of progesterone receptor is required for progesterone antagonism of oestrogen action in the uterus
Progesterone receptor (PGR) is a master regulator of uterine function through antagonistic and synergistic interplays with oestrogen receptors. PGR action is primarily mediated by activation functions AF1 and AF2, but their physiological significance is unknown.
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sg-ntu-dr.10356-1685802023-06-12T15:31:59Z Activation function 1 of progesterone receptor is required for progesterone antagonism of oestrogen action in the uterus Lee, Shi Hao Lim, Chew Leng Shen, Wei Tan, Samuel Ming Xuan Woo, Amanda Rui En Yap, Yeannie H. Y. Sian, Caitlyn Ang Su Goh, Wilson Wen Bin Yu, Wei-Ping Li, Li Lin, Valerie Chun Ling School of Biological Sciences Science::Biological sciences Endometrium Activation Function 1 Progesterone receptor (PGR) is a master regulator of uterine function through antagonistic and synergistic interplays with oestrogen receptors. PGR action is primarily mediated by activation functions AF1 and AF2, but their physiological significance is unknown. Ministry of Education (MOE) Published version This work is supported by the Ministry of Education of Singapore and Academic Research Fund Tier 1 (RG123/19 (S) and Tier II (MOE-T2EP30121-0018)) to Valerie CL Lin and by the National Natural Sciences Foundation of China (31771430) to Li Li. 2023-06-06T06:40:16Z 2023-06-06T06:40:16Z 2022 Journal Article Lee, S. H., Lim, C. L., Shen, W., Tan, S. M. X., Woo, A. R. E., Yap, Y. H. Y., Sian, C. A. S., Goh, W. W. B., Yu, W., Li, L. & Lin, V. C. L. (2022). Activation function 1 of progesterone receptor is required for progesterone antagonism of oestrogen action in the uterus. BMC Biology, 20(1), 222-. https://dx.doi.org/10.1186/s12915-022-01410-3 1741-7007 https://hdl.handle.net/10356/168580 10.1186/s12915-022-01410-3 36199058 2-s2.0-85139439326 1 20 222 en RG123/19 (S) MOE-T2EP30121-0018 BMC biology © 2022 The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativeco mmons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. application/pdf |
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Nanyang Technological University |
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Asia |
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Singapore Singapore |
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| topic |
Science::Biological sciences Endometrium Activation Function 1 |
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Science::Biological sciences Endometrium Activation Function 1 Lee, Shi Hao Lim, Chew Leng Shen, Wei Tan, Samuel Ming Xuan Woo, Amanda Rui En Yap, Yeannie H. Y. Sian, Caitlyn Ang Su Goh, Wilson Wen Bin Yu, Wei-Ping Li, Li Lin, Valerie Chun Ling Activation function 1 of progesterone receptor is required for progesterone antagonism of oestrogen action in the uterus |
| description |
Progesterone receptor (PGR) is a master regulator of uterine function through antagonistic and synergistic interplays with oestrogen receptors. PGR action is primarily mediated by activation functions AF1 and AF2, but their physiological significance is unknown. |
| author2 |
School of Biological Sciences |
| author_facet |
School of Biological Sciences Lee, Shi Hao Lim, Chew Leng Shen, Wei Tan, Samuel Ming Xuan Woo, Amanda Rui En Yap, Yeannie H. Y. Sian, Caitlyn Ang Su Goh, Wilson Wen Bin Yu, Wei-Ping Li, Li Lin, Valerie Chun Ling |
| format |
Article |
| author |
Lee, Shi Hao Lim, Chew Leng Shen, Wei Tan, Samuel Ming Xuan Woo, Amanda Rui En Yap, Yeannie H. Y. Sian, Caitlyn Ang Su Goh, Wilson Wen Bin Yu, Wei-Ping Li, Li Lin, Valerie Chun Ling |
| author_sort |
Lee, Shi Hao |
| title |
Activation function 1 of progesterone receptor is required for progesterone antagonism of oestrogen action in the uterus |
| title_short |
Activation function 1 of progesterone receptor is required for progesterone antagonism of oestrogen action in the uterus |
| title_full |
Activation function 1 of progesterone receptor is required for progesterone antagonism of oestrogen action in the uterus |
| title_fullStr |
Activation function 1 of progesterone receptor is required for progesterone antagonism of oestrogen action in the uterus |
| title_full_unstemmed |
Activation function 1 of progesterone receptor is required for progesterone antagonism of oestrogen action in the uterus |
| title_sort |
activation function 1 of progesterone receptor is required for progesterone antagonism of oestrogen action in the uterus |
| publishDate |
2023 |
| url |
https://hdl.handle.net/10356/168580 |
| _version_ |
1772825609653714944 |