Activation function 1 of progesterone receptor is required for progesterone antagonism of oestrogen action in the uterus

• Main Authors: Lee, Shi Hao, Lim, Chew Leng, Shen, Wei, Tan, Samuel Ming Xuan, Woo, Amanda Rui En, Yap, Yeannie H. Y., Sian, Caitlyn Ang Su, Goh, Wilson Wen Bin, Yu, Wei-Ping, Li, Li, Lin, Valerie Chun Ling
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Biological sciences; Endometrium; Activation Function 1
• Online Access: https://hdl.handle.net/10356/168580
• Institution: Nanyang Technological University

Progesterone receptor (PGR) is a master regulator of uterine function through antagonistic and synergistic interplays with oestrogen receptors. PGR action is primarily mediated by activation functions AF1 and AF2, but their physiological significance is unknown.