Neisseria species as pathobionts in bronchiectasis

• Main Authors: Li, Liang, Aogáin, Micheál Mac, Xu, Tengfei, Jaggi, Tavleen Kaur, Chan, Louisa L. Y., Qu, Jing, Wei, Lan, Liao, Shumin, Cheng, Hong Sheng, Keir, Holly R., Dicker, Alison J., Tan, Kai Sen, Yun, Wang, De, Koh, Mariko Siyue, Ong, Thun How, Lim, Albert Yick Hou, Abisheganaden, John A., Low, Teck Boon, Hassan, Tidi Maharani, Long, Xiang, Wark, Peter A. B., Oliver, Brian, Drautz-Moses, Daniela I., Schuster, Stephan Christoph, Tan, Nguan Soon, Fang, Mingliang, Chalmers, James D., Chotirmall, Sanjay Haresh
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Biological sciences; Neisseria; Microbiome
• Online Access: https://hdl.handle.net/10356/168621
• Institution: Nanyang Technological University

Neisseria species are frequently identified in the bronchiectasis microbiome, but they are regarded as respiratory commensals. Using a combination of human cohorts, next-generation sequencing, systems biology, and animal models, we show that bronchiectasis bacteriomes defined by the presence of Neis...