Structural basis for the inhibitory mechanism of auranofin and gold(I) analogues against Pseudomonas aeruginosa global virulence factor regulator Vfr

• Main Authors: Zhang, Yingdan, Chew, Alvin Bing Liang, Wang, Jing, Yuan, Mingjun, Yam, Joey Kuok Hoong, Luo, Dahai, Yang, Liang
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Medicine; Antimicrobial; Virulence
• Online Access: https://hdl.handle.net/10356/168713
• Institution: Nanyang Technological University

Pseudomonas aeruginosa is a leading cause of hospital-acquired infections. Treatment of P. aeruginosa infections is difficult given its multiple virulence mechanisms, intrinsic antibiotic resistance mechanisms, and biofilm-forming ability. Auranofin, an approved oral gold compound for rheumatoid art...