Generation of allylmagnesium reagents by hydromagnesiation of 2-Aryl-1,3-dienes

• Main Authors: Li, Yihang, Chen, Jiahua, Ng, Jaslyn Jing Wen, Chiba, Shunsuke
• Other Authors: School of Chemistry, Chemical Engineering and Biotechnology
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Chemistry; Hydromagnesiation; Sodium Hydride
• Online Access: https://hdl.handle.net/10356/168875
• Institution: Nanyang Technological University

A protocol for the generation of allylmagnesium reagents from 2-aryl-1,3-dienes was developed using magnesium hydride (MgH2 ) that is generated in situ by solvothermal treatment of sodium hydride (NaH) and magnesium iodide (MgI2 ) in tetrahydrofuran (THF). Downstream functionalization of the resulti...