Interception of enamine intermediates in reductive functionalization of lactams by sodium hydride: synthesis of 2-cyano-3-iodo piperidines and pyrrolidines

Facile conversion of 2-piperidones and 2-pyrrolidones into 2-cyano-3-iodo piperidines or pyrrolidines has been accomplished by the sequence of 1) controlled hydride reduction of lactams using sodium hydride (NaH) in the presence of sodium iodide (NaI); 2) silylation of anionic hemiaminal intermediat...

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Bibliographic Details
Main Authors: Chen, Jiahua, Lim, Jun Wei, Chiba, Shunsuke
Other Authors: School of Physical and Mathematical Sciences
Format: Article
Language:English
Published: 2022
Subjects:
Online Access:https://hdl.handle.net/10356/161610
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Institution: Nanyang Technological University
Language: English