Interception of enamine intermediates in reductive functionalization of lactams by sodium hydride: synthesis of 2-cyano-3-iodo piperidines and pyrrolidines

Interception of enamine intermediates in reductive functionalization of lactams by sodium hydride: synthesis of 2-cyano-3-iodo piperidines and pyrrolidines

Facile conversion of 2-piperidones and 2-pyrrolidones into 2-cyano-3-iodo piperidines or pyrrolidines has been accomplished by the sequence of 1) controlled hydride reduction of lactams using sodium hydride (NaH) in the presence of sodium iodide (NaI); 2) silylation of anionic hemiaminal intermediat...

Full description

Saved in:
Bibliographic Details
Main Authors: Chen, Jiahua, Lim, Jun Wei, Chiba, Shunsuke
Other Authors: School of Physical and Mathematical Sciences
Format: Article
Language:English
Published: 2022
Subjects:
Science::Chemistry
Sodium Hydride
Lactams
Online Access:https://hdl.handle.net/10356/161610
Tags: Add Tag
No Tags, Be the first to tag this record!
Institution: Nanyang Technological University
Language: English

Internet

https://hdl.handle.net/10356/161610

Similar Items