Genomic, transcriptomic, and metabolomic analysis of Oldenlandia corymbosa reveals the biosynthesis and mode of action of anti-cancer metabolites

• Main Authors: Julca, Irene, Mutwil-Anderwald, Daniela, Manoj, Vaishnervi, Khan, Zahra, Lai, Soak Kuan, Yang, Lay K., Beh, Ing Tsyr, Dziekan, Jerzy, Lim, Yoon P., Lim, Shen Kiat, Low, Yee W., Lam, Yuen In, Tjia, Seth, Mu, Yuguang, Tan, Qiao Wen, Nuc, Przemyslaw, Choo, Le M., Khew, Gillian, Shining, Loo, Kam, Antony, Tam, James P., Bozdech, Zbynek, Schmidt, Maximilian, Usadel, Bjoern, Kanagasundaram, Yoganathan, Alseekh, Saleh, Fernie, Alisdair, Li, Hoi Y., Mutwil, Marek
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Biological sciences; Genome; Metabolomics
• Online Access: https://hdl.handle.net/10356/169174
• Institution: Nanyang Technological University

Plants accumulate a vast array of secondary metabolites, which constitute a natural resource for pharmaceuticals. Oldenlandia corymbosa belongs to the Rubiaceae family, and has been used in traditional medicine to treat different diseases, including cancer. However, the active metabolites of the pla...