Molecular analysis of antimalarial therapies : from drug development to mode of action

by Dziekan, Jerzy Michal
Published 2019

Identification and structural validation of purine nucleoside phosphorylase from Plasmodium falciparum as a target of MMV000848

by Chung, Zara, Lin, Jianqing, Wirjanata, Grennady, Dziekan, Jerzy Michal, El Sahili, Abbas, Preiser, Peter Rainer, Bozdech, Zbynek, Lescar, Julien
Published 2024

Identifying purine nucleoside phosphorylase as the target of quinine using cellular thermal shift assay

by Dziekan, Jerzy Michal, Yu, Han, Chen, Dan, Dai, Lingyun, Wirjanata, Grennady, Larsson, Andreas, Prabhu, Nayana, Sobota, Radoslaw Mikolaj, Bozdech, Zbynek, Nordlund, Pär
Published 2021

Plasmodium falciparum eukaryotic translation initiation factor 3 is stabilized by quinazoline-quinoline bisubstrate inhibitors

by Dobrescu, Irina, Hammam, Elie, Dziekan, Jerzy Michal, Claës, Aurélie, Halby, Ludovic, Preiser, Peter, Bozdech, Zbynek, Arimondo, Paola B., Scherf, Artur, Nardella, Flore
Published 2024

Short tandem repeat polymorphism in the promoter region of cyclophilin 19B drives its transcriptional upregulation and contributes to drug resistance in the malaria parasite Plasmo...

by Kucharski, Michal, Wirjanata, Grennady, Nayak, Sourav, Boentoro, Josephine, Dziekan, Jerzy Michal, Assisi, Christina, van der Pluijm, Rob W., Miotto, Olivo, Mok, Sachel, Dondorp, Arjen M., Bozdech, Zbynek
Published 2023

Genetic validation of PfFKBP35 as an antimalarial drug target

by Thommen, Basil T., Dziekan, Jerzy Michal, Achcar, Fiona, Tjia, Seth, Passecker, Armin, Buczak, Katarzyna, Gumpp, Christin, Schmidt, Alexander, Rottmann, Matthias, Grüring, Christof, Marti, Matthias, Bozdech, Zbynek, Brancucci, Nicolas MB
Published 2024

Cellular thermal shift assay for the identification of drug-target interactions in the Plasmodium falciparum proteome

by Dziekan, Jerzy Michal, Wirjanata, Grennady, Dai, Lingyun, Go, Ka Diam, Yu, Han, Lim, Yan Ting, Chen, Liyan, Wang, Loo Chien, Puspita, Brenda, Prabhu, Nayana, Sobota, Radoslaw M., Nordlund, Pär, Bozdech, Zbynek
Published 2022

Human peroxiredoxin 6 is essential for malaria parasites and provides a host-based drug target

by Wagner, Matthias Paulus, Formaglio, Pauline, Gorgette, Olivier, Dziekan, Jerzy Michal, Huon, Christèle, Berneburg, Isabell, Rahlfs, Stefan, Barale, Jean-Christophe, Feinstein, Sheldon I., Fisher, Aron B., Ménard, Didier, Bozdech, Zbynek, Amino, Rogerio, Touqui, Lhousseine, Chitnis, Chetan E.
Published 2023

Genomic, transcriptomic, and metabolomic analysis of Oldenlandia corymbosa reveals the biosynthesis and mode of action of anti-cancer metabolites

by Julca, Irene, Mutwil-Anderwald, Daniela, Manoj, Vaishnervi, Khan, Zahra, Lai, Soak Kuan, Yang, Lay K., Beh, Ing Tsyr, Dziekan, Jerzy, Lim, Yoon P., Lim, Shen Kiat, Low, Yee W., Lam, Yuen In, Tjia, Seth, Mu, Yuguang, Tan, Qiao Wen, Nuc, Przemyslaw, Choo, Le M., Khew, Gillian, Shining, Loo, Kam, Antony, Tam, James P., Bozdech, Zbynek, Schmidt, Maximilian, Usadel, Bjoern, Kanagasundaram, Yoganathan, Alseekh, Saleh, Fernie, Alisdair, Li, Hoi Y., Mutwil, Marek
Published 2023