Cryo-EM structure of the Mycobacterium abscessus F1-ATPase

• Main Authors: Wong, Chui Fann, Leow, Chen Yen, Grüber, Gerhard
• 其他作者: School of Biological Sciences
• 格式: Article
• 語言: English
• 出版: 2023
• 主題: Science::Biological sciences::Biochemistry; Science::Biological sciences::Biophysics; ATP Synthase; Bioenergetics; Electron Microscopy; Infectious Diseases; Mycobacterium; Non-Tuberculous Mycobacteria
• 在線閱讀: https://hdl.handle.net/10356/169214
• 機構: Nanyang Technological University

The cases of lung disease caused by non-tuberculous mycobacterium Mycobacterium abscessus (Mab) are increasing and not reliably curable. Repurposing of anti-tuberculosis inhibitors brought the oxidative phosphorylation pathway with its final product ATP, formed by the essential F1FO-ATP synthase (su...