Membrane potential-dependent uptake of cationic oligoimidazolium mediates bacterial DNA damage and death

• Main Authors: Yong, Melvin, Kok, Zhi Y., Koh, Chong Hui, Zhong, Wenbin, Ng, Justin T. Y., Mu, Yuguang, Chan-Park, Mary B., Gan, Yunn-Hwen
• 其他作者: School of Chemistry, Chemical Engineering and Biotechnology
• 格式: Article
• 語言: English
• 出版: 2023
• 主題: Science::Biological sciences; Engineering::Bioengineering; DNA Damage; Cationic
• 在線閱讀: https://hdl.handle.net/10356/169440
• 機構: Nanyang Technological University

The treatment of bacterial infections is becoming increasingly challenging with the emergence of antimicrobial resistance. Thus, the development of antimicrobials with novel mechanisms of action is much needed. Previously, we designed several cationic main-chain imidazolium compounds and identified...