A phase I/II randomized, double-blinded, placebo-controlled trial of a self-amplifying Covid-19 mRNA vaccine

• Main Authors: Low, Jenny G., de Alwis, Ruklanthi, Chen, Shiwei, Kalimuddin, Shirin, Leong, Yan Shan, Mah, Tania Ken Lin, Yuen, Natalene, Tan, Hwee Cheng, Zhang, Summer L., Sim, Jean X. Y., Chan, Yvonne F. Z., Syenina, Ayesa, Yee, Jia Xin, Ong, Eugenia Z., Sekulovich, Rose, Sullivan, Brian B., Lindert, Kelly, Sullivan, Sean M., Chivukula, Pad, Hughes, Steven G., Ooi, Eng Eong
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Biological sciences; SARS-CoV-2 Vaccine; Neutralizing Antibody
• Online Access: https://hdl.handle.net/10356/169469
• Institution: Nanyang Technological University

Coronavirus disease-19 (Covid-19) pandemic have demonstrated the importantance of vaccines in disease prevention. Self-amplifying mRNA vaccines could be another option for disease prevention if demonstrated to be safe and immunogenic. Phase 1 of this randomized, double-blinded, placebo-controlled tr...