ZnT8 loss of function mutation increases resistance of human embryonic stem cell-derived beta cells to apoptosis in low zinc condition
The rare SLC30A8 mutation encoding a truncating p.Arg138* variant (R138X) in zinc transporter 8 (ZnT8) is associated with a 65% reduced risk for type 2 diabetes. To determine whether ZnT8 is required for beta cell development and function, we derived human pluripotent stem cells carrying the R138X m...
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Main Authors: | Sui, Lina, Du, Qian, Romer, Anthony, Su, Qi, Chabosseau, Pauline L., Xin, Yurong, Kim, Jinrang, Kleiner, Sandra, Rutter, Guy A., Egli, Dieter |
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Other Authors: | Lee Kong Chian School of Medicine (LKCMedicine) |
Format: | Article |
Language: | English |
Published: |
2023
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Subjects: | |
Online Access: | https://hdl.handle.net/10356/169483 |
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Institution: | Nanyang Technological University |
Language: | English |
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