Dependency of NELF-E-SLUG-KAT2B epigenetic axis in breast cancer carcinogenesis

• Main Authors: Zhang, Jieqiong, Hu, Zhenhua, Chung, Hwa Hwa, Tian, Yun, Lau, Kah Weng, Ser, Zheng, Lim, Yan Ting, Sobota, Radoslaw M., Leong, Hwei Fen, Chen, Benjamin Jieming, Yeo, Clarisse Jingyi, Tan, Shawn Ying Xuan, Kang, Jian, Tan, Dennis Eng Kiat, Sou, Ieng Fong, McClurg, Urszula Lucja, Lakshmanan, Manikandan, Vaiyapuri, Thamil Selvan, Raju, Anandhkumar, Wong, Esther Sook Miin, Tergaonkar, Vinay, Rajarethinam, Ravisankar, Pathak, Elina, Tam, Wai Leong, Tan, Ern Yu, Tee, Wee-Wei
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Medicine; Elongation Factor; Cancer Prognosis
• Online Access: https://hdl.handle.net/10356/169765
• Institution: Nanyang Technological University

Cancer cells undergo transcriptional reprogramming to drive tumor progression and metastasis. Using cancer cell lines and patient-derived tumor organoids, we demonstrate that loss of the negative elongation factor (NELF) complex inhibits breast cancer development through downregulating epithelial-me...