Beyond the TPP+ "gold standard": a new generation mitochondrial delivery vector based on extended PN frameworks

• Main Authors: Ong, How Chee, Coimbra, João T. S., Ramos, Maria J., Xing, Bengang, Fernandes, Pedro A., García, Felipe
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Chemistry; Triphenylphosphonium; Lipophilicity
• Online Access: https://hdl.handle.net/10356/169778
• Institution: Nanyang Technological University

Mitochondrial targeting represents an attractive strategy for treating metabolic, degenerative and hyperproliferative diseases, since this organelle plays key roles in essential cellular functions. Triphenylphosphonium (TPP+) moieties - the current "gold standard" - have been widely used a...