Molecular functions of the nuclear lamina in premature cell ageing

• Main Author: Foo, Mattheus Xing Rong
• Other Authors: Peter Droge
• Format: Thesis-Doctor of Philosophy
• Language: English
• Published: Nanyang Technological University 2023
• Subjects: Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/169879
• Institution: Nanyang Technological University

Hutchinson-Gilford Progeria Syndrome (HGPS) is a premature ageing syndrome that manifests as early as 1 year of age. Patients exhibit severe phenotypes such as bone defects, cardiovascular complications, and a mean lifespan of 14 years. HGPS is caused by a silent heterozygous mutation that results i...