Molecular functions of the nuclear lamina in premature cell ageing

• المؤلف الرئيسي: Foo, Mattheus Xing Rong
• مؤلفون آخرون: Peter Droge
• التنسيق: Thesis-Doctor of Philosophy
• اللغة: English
• منشور في: Nanyang Technological University 2023
• الموضوعات: Science::Biological sciences
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/169879
• المؤسسة: Nanyang Technological University

Hutchinson-Gilford Progeria Syndrome (HGPS) is a premature ageing syndrome that manifests as early as 1 year of age. Patients exhibit severe phenotypes such as bone defects, cardiovascular complications, and a mean lifespan of 14 years. HGPS is caused by a silent heterozygous mutation that results i...